Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other indicators from your microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have determined recurrent mutations in genes regulating tumor cell-microenvironment interactions... https://bethk776gxo5.blogpixi.com/profile